After growing up in beautiful Wachenheim (Germany) and a highschool year in St.Louis (USA) with YfU/PPP I studied molecular biology and informatics at the universities of Freiburg and Heidelberg. I obtained my diploma and PhD at the German Cancer Research Center (DKFZ) Heidelberg.
Working for Ensembl and then for the ENCODE project at the Wellcome Trust Sanger Institute as a Bioinformatician brought me to Cambridge (UK). I then joined the Cambridge start-up company BlueGnome Ltd. as a senior Bioinformatician which has since become part of Illumina Inc.
My interest and experience are in the area of genome bioinformatics. Topics include: Genomic microarrays (aCGH), Next-Generation Sequencing applications, data integration, gene prediction and genome annotation.
Genome annotation and analysis.
The genetic make-up of many organisms, including human, has been deciphered.
One of the great tasks of our time is the interpretation and usage of this information.
Important steps in this process are the identification of functional elements and their interconnection using laboratory and computational methods.
Data management and data integration in genome research
One key to this understanding is the integration of all data available. By combining heterogeneous data
sources (databases, flat files, web services, etc.), literature, laboratory data and bioinformatic analysis
we will learn more about how life works and how to better target certain diseases.
Available software projekts:
in collaboration with Gunnar Wrobel (2001-2003)
A simple MS Access database system as an example for a laboratory data management systems for microarray facilities.
Quite old now, but a useful example of early tools for the trade using VBA programming.
in collaboration with Gunnar Wrobel (2003-2004)
Tool for the rapid generation of primer sequences for RealTime-PCR experiments.
Started out of curiosity and grown to still be used by many researches around the world.
in collaboration with Gunnar Wrobel and Nicolas Delhomme (2001-2005)
Flexible framework for the interpretation of data from high-throughput experiments.
Used for the explorative analysis with potential to be expanded to various data sources.
joint project between the EMBL/EBI and the Wellcome Trust Sanger Institute
Software system which produces and maintains automatic annotation of metazoan genomes.
A world-leading source of genome annotation and an excellent API for data extraction.
[source code and data]
As part of the ENCODE project (2008-2011)
Genome annotation tracking system based on the project management software Redmine
Web-based tool to organise multiple annotation projects.
[source code and data]